Binding and Functional Folding (BFF): A Physiological Framework for Studying Biomolecular Interactions and Allostery

Brianna D. Young,Mary E. Cook,Brianna K. Costabile,Riya Samanta, Xinhao Zhuang,Spiridon E. Sevdalis,Kristen M. Varney,Filippo Mancia,Silvina Matysiak,Eaton Lattman,David J. Weber

Journal of Molecular Biology（2022）

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摘要

•CBPs and their targets deliver cell function(s) via oscillations in free [Ca2+].•The BFF physiological framework for studying binding and allostery will be illustrated here with CBPs.•A type 1 BFF event is concerted within a physiologically relevant timeframe and a type 2 BFF mechanism is stepwise.

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关键词

allostery,Ca2+-signaling,S100 proteins,calmodulin,binding and functional folding

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