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Annexin A2 promotes angiogenesis after ischemic stroke via annexin A2 receptor – AKT/ERK pathways

Haoran Lin,Wenlu Li,Zexu Shen,Yun Bei,Taofeng Wei,Zhanyang Yu,Yunjian Dai,Haibin Dai

Neuroscience Letters（2023）

Cited 3|Views12
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Abstract
•Annexin A2 (ANXA2) attenuated OGD injury and improved behavioral recovery after focal cerebral ischemia.•ANXA2 increased tube-formation and migration of brain endothelial cells either under normal condition or after OGD injury and promoted angiogenesis after focal cerebral ischemia.•ANXA2 interacted with ANXA2 receptor to activate AKT/ERK pathways and then increased tube-formation and migration of brain endothelial cells after OGD injury.
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Stroke,Angiogenesis,Endothelial cells,Annexin A2,Annexin A2 receptor
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