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CLIF-C AD score predicts survival benefit from pre-emptive TIPS in individuals with Child-Pugh B cirrhosis and acute variceal bleeding

Yong Lv,Wei Bai,Xuan Zhu,Hui Xue,Jianbo Zhao,Yuzheng Zhuge,Junhui Sun,Chunqing Zhang,Pengxu Ding,Zaibo Jiang,Xiaoli Zhu,Weixin Ren,Yingchun Li,Kewei Zhang,Wenguang Zhang,Kai Li,Zhengyu Wang,Bohan Luo,Xiaomei Li,Zhiping Yang

JHEP Reports（2022）

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Abstract
•In those with Child-Pugh B cirrhosis and acute variceal bleeding, CLIF-C AD score could predict survival benefit from pre-emptive TIPS.•Active bleeding at endoscopy was associated with increased mortality in individuals with Child-Pugh B8-9 (but not B7) cirrhosis.•Pre-emptive TIPS improves survival in individuals with Child-Pugh B8-9 cirrhosis and active bleeding at endoscopy.•CLIF-C AD score is superior to active bleeding + Child-Pugh B8-9 to predict survival benefit with preemptive TIPS.
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Key words
Cirrhosis,Variceal bleeding,Portal hypertension,Transjugular intrahepatic portosystemic shunt,Risk stratification
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