Exploring α-Amylase Inhibitory Activity of Cow’s Urine Extract of Alternanthera sessilis

Background and Objective: The current "-amylase and "-glucosidase inhibitors in clinical use such as acarbose, miglitol and voglibose are associated with undesirable side effects such as hypoglycemia, flatulence and diarrhoea due to the inhibitory effect of gastrointestinal digestion which limits their use in the treatment of diabetes when compared to the active principles of plant origin.This study explores the antidiabetic enhancing property of Alternanthera sessilis with cowʼs urine as compared to aqueous extract.Materials and Methods: The aqueous and cowʼs urine extract of Alternanthera sessilis was prepared by maceration and both extracts were subjected for in vitro "-amylase inhibitory activity.The obtained data were compared and analysed by MS office excel.Results: Cow urine has enhanced the time of hydrolysis of starch by "-amylase, which in turn exhibited an inhibitory effect on the "-amylase enzyme. Conclusion:From the research work it was revealed that cowʼs urine extract shows promising "-amylase inhibitory activity compared to aqueous extract.The cowʼs urine distillate as a solvent for the extraction and compare the "-amylase inhibitory activity of cowʼs urine extract with aqueous extract and analyze the bio-enhancing effect on bio-active principles of aqueous extract.