Establishment of an oral squamous cell carcinoma cell line expressing vascular endothelial growth factor a and its two receptors

Hanako Araki-Maeda,Mutsuki Kawabe,Yuji Omori,Koji Yamanegi,Kazunari Yoshida,Kyohei Yoshikawa,Kazuki Takaoka,Kazuma Noguchi,Yoshiro Nakano,Hiromitsu Kishimoto

Journal of Dental Sciences（2022）

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摘要

We established an OSCC cell line, HCM-SqCC010, that expresses VEGF-A, VEGFR-1, and VEGFR-2. This triple-positive cell line showed no effect from a molecular targeted drug toward VEGF-A, but it did show strong cell growth inhibition in response to a VEGFR inhibitor. Thus, new therapeutic strategies against OSCC should include a VEGFR inhibitor.

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Oral squamous cell carcinoma,VEGF-A,VEGFR-1,VEGFR-2

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