Longitudinal Brain Atrophy Rates in Presymptomatic Carriers of Genetic Frontotemporal Dementia.

Jackie M Poos,Leonie D M Grandpierre,Emma L van der Ende,Jessica L Panman,Janne M Papma,Harro Seelaar,Esther van den Berg,Ronald van 't Klooster,Esther Bron,Rebecca Steketee,Meike W Vernooij,Yolande A L Pijnenburg,Serge A R B Rombouts,John van Swieten,Lize C Jiskoot

Neurology（2022）

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摘要

We provide evidence for longitudinal brain atrophy in the presymptomatic stage of genetic FTD. The affected brain areas and the age after which atrophy rates start to accelerate and diverge from normal aging slopes differed between gene groups. These results highlight the value of normative volumetry software for disease-tracking and staging biomarkers in genetic FTD. These techniques could help in identifying the optimal time window for starting treatment and monitoring treatment response.

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关键词

dementia,presymptomatic carriers,brain

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