Sox2 is required in supporting cells for normal levels of vestibular hair cell regeneration in adult mice

•We deleted Sox2 from vestibular supporting cells in adult mice prior to hair cell damage.•We found that Sox2 is required in supporting cells for normal levels of hair cell regeneration.•Sox2 deletion did not alter supporting cell density, morphology, or ultrastructure.•More hair cells survived diphtheria toxin-mediated damage in mice with Sox2 deletion.•Our study provides new insights into Sox2’s roles in adult mouse supporting cells.