Insect nephrocyte function is regulated by a store operated calcium entry mechanism controlling endocytosis and Amnionless turnover

•Insect nephrocytes display dynamic calcium signalling in vivo.•Disrupting calcium signalling reduced endocytosis by nephrocytes.•The Store Operated Calcium Entry genes Stim and Orai mediate nephrocyte function.•Calcium signalling modulates the turnover of the endocytic coreceptor Amnionless.