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Early‐phase prothrombin time‐international normalized ratio in acute liver injury indicates the timing of therapeutic intervention and predicts prognostic improvement

Kotaro Kumagai,Seiichi Mawatari,Akihiro Moriuchi,Kohei Oda,Yasuhiro Takikawa,Naoya Kato,Shigeto Oda,Kazuaki Inoue,Shuji Terai,Takuya Genda,Masahito Shimizu,Isao Sakaida,Satoshi Mochida,Akio Ido

Hepatology Research（2022）

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Abstract
Early-phase changes in the PT-INR can predict the prognosis of patients with acute liver injury and acute liver failure. Furthermore, PT-INR ≥1.3 could be an interventional marker, whereas PT-INR <1.3 after 1 week could reflect prognostic improvement.
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Key words
acute liver failure,acute liver injury,international normalized ratio,prognosis,prothrombin,treatment
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