Gut-derived Endotoxin-TLR4 Signaling Drives MYC-Ig Translocation to Promote Lymphoproliferation through c-JUN and STAT3 Activation.

Ahmed Rokan,Juan Carlos Hernandez,Rajeshwar Nitiyanandan, Zi-Ying Lin,Chia-Lin Chen,Tatsuya Machida,Meng Li, Jasleen Khanuja, Mo Li Chen,Stanley M Tahara,Imran Siddiqi,Keigo Machida

Molecular cancer research : MCR（2023）

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摘要

Obesity increases gut-derived endotoxin which induces Toll-like receptor-mediated MYC-Ig translocation via c-JUN-STAT3, leading to lymphoproliferation.

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关键词

promote lymphoproliferation,signaling drives,gut-derived,c-jun

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