Sohlh2 Regulates the Stemness and Differentiation of Colon Cancer Stem Cells by Downregulating LncRNA-H19 Transcription.

Ruihong Zhang,Xiaoli Zhang,Wenfang Zhang,Weiwei Cui,Yunling Xiao,Lanlan Liu,Sujuan Zhi,Xiaoning Feng,Xuyue Liu,Ying Shen,Jie Chai,Jing Hao

Molecular cancer research : MCR（2023）

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摘要

This study identifies that Sohlh2 directly manipulates LncRNA-H19 transcription and suppresses the β-catenin signaling pathway and the Sohlh2/LncRNA-H19/miR-141/β-catenin signaling pathway plays an essential role in the stemness of colon CSCs.

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关键词

colon cancer stemness cells,sohlh2

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