Regulation of caries-induced pulp inflammation by NLRP3 inflammasome: A laboratory-based investigation.

Banan Al Natour,Fionnuala T Lundy,Imad About,Charlotte Jeanneau,Yvonne Dombrowski,Ikhlas A El Karim

International endodontic journal（2023）

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摘要

Expression and upregulation of NLRP3 inflammasome with caries and LTA treatment suggest a role in caries-induced pulpitis. NLRP3 inhibitor attenuated the release of selective inflammatory cytokines and could be a potential treatment target that merit further investigation.

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关键词

NLRP3 inflammasome,caries bacteria,cell death,pulp death,pulpitis,vital pulp treatment

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