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Combining curcumin and aspirin ameliorates preeclampsia-like symptoms by inhibiting the placental TLR4/NF-κB signaling pathway in rats.

Yaru Ju,Yan Feng,Yanjing Yang,Xiaolin Hou,Xiaofeng Zhang,Xihui Zhu,Yage Wang,Meiliu Yang

Journal of Obstetrics and Gynaecology Research（2023）

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Abstract
Our results suggested that the combined treatment of curcumin and aspirin significantly ameliorates the symptoms of PE in rats, which is most likely due to the inhibition of the placental TLR4/NF-κB p65 signaling pathway.
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Key words
TLR4/NF-κB,aspirin,curcumin,inflammation,oxidative stress,preeclampsia
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