Nuclear DNA SNP Profiles Derived from Human Hair Shaft
Forensic Science International: Genetics Supplement Series(2022)
Abstract
DNA from rootless hair shaft is fragmented and in low abundance. We have developed methods using capture hybridization and massively parallel sequencing to generate nuclear genotype profiles from hair. Using a panel targeting 215 SNP loci highly informative for ancestry and identity, our results elicited a probability of inclusion of approximately one in greater than 9.6E+39. This shows the potential of this approach to obtain nuclear genotype information from hair shaft DNA.
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Key words
DNA sequencing,Capture hybridization,Hair shaft DNA
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