The Pregnane X Receptor and Indole-3-Propionic Acid Shape the Intestinal Mesenchyme to Restrain Inflammation and Fibrosis.

Kyle L Flannigan,Kristoff M Nieves,Holly E Szczepanski, Alex Serra,Joshua W Lee,Laurie A Alston,Hena Ramay,Sridhar Mani,Simon A Hirota

Cellular and molecular gastroenterology and hepatology（2022）

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摘要

These data highlight a role for IPA and its interactions with the PXR in regulating the mesenchyme and the development of inflammation and fibrosis, suggesting microbiota metabolites may be a vital determinant in the progression of fibrotic complications in IBD.

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Intestinal fibrosis,fibroblasts,microbiota,pregnane X receptor

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