Development of new Ti50Zr25Nb20Cu5–xAgx high-entropy alloys with excellent antibacterial property, osteo-conductivity and biocompatibility in vitro and in vivo

Bingxiao Yu,Talante Juma,Hao Wang,Xiaotong Bao,Xiangyu Cao,Zhiwen Wang, Rui Wang,Xin Yang,Taiguo Ning,Guanghua Liang,Yongping Cao,Tao Zhang,Zhenpeng Guan

Journal of Materials Science & Technology（2023）

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摘要

•New Zr–Ti–Nb–Cu–Ag high-entropy alloys(HEAs), especially HEACu2.5Ag2.5 showed better antibacterial ability against Staphylococcus aureus than Ti–6Al–4V.•Excellent osteo-conductivity of HEAs was observed in vitro.•HEACu2.5Ag2.5 can prevent serious bacterial infections peri-implants, with a lower PCT in infection models.

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关键词

High-entropy alloys,Implant infection,Metal anti-bacteria,Biofilm,Osteo-conductivity,Biocompatibility

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