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An RSV Live-Attenuated Vaccine Candidate Lacking G Protein Mucin Domains Is Attenuated, Immunogenic, and Effective in Preventing RSV in BALB/c Mice.

Molly K Roe,Maria A Perez,Hui-Mien Hsiao,Stacey A Lapp,He-Ying Sun,Samadhan Jadhao,Audrey R Young,Yara S Batista,Ryan C Reed,Azmain Taz,Anne Piantadosi,Xuemin Chen,Bo Liang,Michael Koval,Timothy A Snider,Martin L Moore,Evan J Anderson,Larry J Anderson,Christopher C Stobart,Christina A Rostad

The Journal of infectious diseases（2022）

Cited 1|Views8
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Abstract
Removal of the G-protein mucin domains produced RSV LAV candidates that were highly attenuated with retained immunogenicity.
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Key words
RSV,glycoprotein,glycosylation,live-attenuated vaccine,mucin domains,pediatric
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