Probing human proteins for short encrypted antimicrobial peptides reveals Hs10, a peptide with selective activity for gram-negative bacteria

Michele A Santos,Fernanda L Silva,Bianca O V Lira,José L Cardozo Fh,Andreanne G Vasconcelos,Alyne R Araujo,André M Murad,Aisel V Garay,Sonia M Freitas,José Roberto S A Leite,Carlos Bloch,Marcelo H S Ramada,Aline Lima de Oliveira,Guilherme D Brand

Biochimica et Biophysica Acta (BBA) - General Subjects（2023）

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摘要

•Human proteome was mined for cationic and amphiphilic segments with β-sheet periodicity.•Some segments were synthesized and tested, with MICs in micromolar scale.•One peptide, Hs10, inhibited only Gram-negative bacteria, with little cytotoxicity.•LPS was characterized as a relevant binding partner for Hs10.•Cationic and amphiphilic β-sheets encrypted in human proteins serve as antibiotics.

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关键词

Novel antibiotics,Proteome,Antimicrobial peptides,Kamal

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