Utility of Non-invasive Monitering for Predicting Late-onset Adverse Reaction

Late-onset adverse body reactions after blood donation are a serious problem when considering the safety of donors. However, predicting these reactions at the donation office can be difficult because their pathophysiology is poorly understood. We non-invasively monitored the cardiac output (CO) and stroke volume (SV) of 72 donors during autologous blood donation using an AESCULON mini device. The original preoperative autologous blood donation adverse reaction scale (PADARS) was used to estimate the severity of post-donation body reactions. The relationship between the total PADARS score and AESCULON mini measurements and other backgrounds was evaluated using a multivariate linear regression model. During the donation, the average decrease in CO and SV was 0.79±0.43l/min and 9.4±6.7ml, respectively. Among 30 donors who answered the questionnaire, 14 (47%) and 2 (7%) were aware of some subjective symptoms and suffered from relatively severe body reactions (score ≥ 5), respectively. A multivariate linear regression analysis revealed that age and SV value at the end of donation were inversely correlated with the total PADARS score (p < 0.05). In addition to younger age, a low post-donation SV value measured by AESCULON mini can be a risk factor for late-onset adverse body reactions.