Neuroimaging in Leber Hereditary Optic Neuropathy: State-of-the-art and future prospects

•MRI reveals that LHON’s neural aetiology includes impacts beyond the retina.•Effects are not limited to visual structures, but extend to non-visual regions.•Why and when changes occur and link to function and other diseases remains unclear.•New MRI methods (e.g., qMRI, g-ratio) may provide mechanistic insights into LHON.•MRI could help inform and understand the effect of future therapies for LHON.