阿帕替尼的合成路线图解

TANG Ming-hong, MENG Xin-chi, CUI Fei-xue, YANG Shang-jie, SHI Qi,Chen Shi,JIANG Chun-feng

Journal of Liaoning Institute of Science and Technology（2022）

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Abstract

阿帕替尼(商品名:艾坦)是由我国恒瑞医药自主研发的全球第一个治疗晚期胃癌的小分子靶向抗肿瘤药物,2014年获批上市.本文对阿帕替尼的合成路线进行了综述与分析,以期望为工业化生产提供新的思路.

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