IQGAP3 in clear cell renal cell carcinoma contributes to drug resistance and genome stability.

Wen Li,Zhifeng Wang,Hanlin Wang,Jian Zhang,Xiaobin Wang,Shaojun Xing,Si Chen

PeerJ（2022）

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摘要

The highly expressed IQGAP3 in multiple subtypes of renal cell carcinoma has a clear prognostic value. Deletion of IQGAP3 inhibits cell growth in 3D Matrigel. IQGAP3 depletion lso increases accumulated DNA damage, and improves cell sensitivity to ionizing radiation and chemotherapeutic drugs. Therefore, targeting DNA damage repair function of IQGAP3 in tumorigenesis can provide ideas for the development of new targets for early diagnosis.

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关键词

Clear cell renal clear cell carcinoma, DNA damage repair,Drug resistance,Genomic stability,IQGAP3

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