Combined HPV 16 E2 and L1 methylation predict response to treatment with cidofovir and imiquimod in patients with vulval intraepithelial neoplasia.

Christopher Nicholas Hurt,Belinda Nedjai, Carlos Alvarez-Mendoza,Ned Powell,Amanda Tristram,Sadie Jones

Cancer biomarkers : section A of Disease markers（2022）

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摘要

Combined HPV E⁢2 and L⁢1 methylation is a potential predictive marker in treatment for all patients with VIN. These findings justify validation in a prospective trial.

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关键词

HPV,Vulval intraepithelial neoplasia,cidofovir,gene methylation,imiquimod,predictive biomarker

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