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胡桃醌对胃癌SGC-7901细胞增殖、侵袭和糖酵解的影响

YU Pingping,JIN Xiaosheng

Chinese Journal of Traditional Medical Science and Technology（2022）

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Abstract
目的:研究胡桃醌对胃癌SGC-7901细胞增殖、侵袭和糖酵解的影响,并进一步探讨其分子机制.方法:MTT法和细胞克隆实验检测胡桃醌对SGC-7901细胞增殖的影响;流式细胞术检测胡桃醌对SGC-7901细胞周期的影响;划痕实验和transwell侵袭实验检测胡桃醌对SGC-7901细胞迁移和侵袭的影响;ELISA检测胡桃醌对SGC-7901细胞糖酵解的影响;Western blot检测糖酵解相关蛋白以及AKT/mTOR信号通路蛋白的变化.结果:胡桃醌能够有效抑制SGC-7901细胞的增殖,阻滞SGC-7901细胞于G0/G1期,能够显著抑制SGC-7901细胞的迁移和侵袭,降低SGC-7901细胞糖酵解反应,并且抑制AKT/mTOR信号通路的活性,与空白对照组相比均有显著性差异(P＜0.05).结论:胡桃醌能够抑制胃癌SGC-7901细胞增殖、侵袭和糖酵解,其机制与抑制AKT/mTOR信号通路有关.
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