Copper- and Visible-Light-Catalyzed Cascade Radical Cyclization of N‑Propargylindoles with Cyclic Ethers
The Journal of organic chemistry(2023)
Abstract
An efficient visible-light-assisted, copper-catalyzed tandem radical cyclization of N-propargylindoles with cyclic ethers is established. A series of 2-oxoalkyl-9H-pyrrolo[1,2-a]indol-9-ones with potential biological activities were synthesized in moderate yields by using a dual catalytic system with copper acetate as a transition metal catalyst and eosin Y as a visible light catalyst. The investigation of reaction mechanism shows that it goes through a cascade oxoalkyl radical addition, cyclization, and oxidation process.
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Key words
visible-light-catalyzed
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