Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss

Andrew Clark,Subhadip Ghatak,Poornachander Reddy Guda,Mohamed S. El Masry,Yi Xuan,Amy Y. Sato,Teresita Bellido,Chandan K. Sen

NPJ REGENERATIVE MEDICINE（2022）

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摘要

This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNT MyoD ) to injured tissue in vivo. TNT MyoD was performed on skin and successfully induced expression of myogenic factors. TNT MyoD was then used as a therapy 7 days following volumetric muscle loss (VML) of rat tibialis anterior and rescued muscle function. TNT MyoD is promising as VML intervention.

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myogenic tissue nanotransfection,muscle torque recovery

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