Extract of Ginkgo biloba leaves attenuates neurotoxic damages in rats and SH-SY5Y cells exposed to a high level of fluoride
Journal of Trace Elements in Medicine and Biology(2023)
Abstract
•Chronic fluorosis decreased learning and memory of rats and induced neurotoxicity.•Ginkgo biloba attenuates the impairment of brain and the neurotoxicity in rats with chronic fluorosis and SH-SY5Y cells exposed to fluoride.•The underlying mechanism in that the Ginkgo biloba extract attenuated neurotoxic damage induced by fluorosis may involve inhibition of PARP-1 activity and promotion of the expression of SIRT1.
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Key words
Fluoride,Ginkgo biloba extract,Neurotoxicity,Rats,SH-SY5Y cells
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