Mathematical and experimental validation of an approach for simultaneously determining the binding parameters of two drugs to a receptor

Sai Qiao,Yuanyuan Ou, Lun Liu,Siwang Wang,Liujiao Bian,Xinfeng Zhao

Journal of Chromatography A（2022）

引用 3|浏览11

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摘要

•A new equation for drug-protein interaction analysis was derivatized.•Co-injection of two drugs was realized for measurement of drug-protein binding.•Two-fold higher throughput than typical chromatographic assays was confirmed.

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关键词

Drug-protein interaction,Affinity chromatography,Immobilized endothelin A receptor,Association constant

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