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Mitochondria-Targeted and pH-Triggered Charge-Convertible Polymeric Micelles for Anticancer Therapy

Lingli Jin,Yanwen Xu,Fengjiao Chen,Dingle Yu,Hongze Liang,Zhenjiang Liang,Ziyu Liu,Haiyan Li,Junying Liu,Hui Tan,Lingling Zhao

Materials & Design（2022）

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Abstract
•Mitochondria-targeted and pH-triggered charge-convertible polymeric micelles were developed for targeted DOX delivery.•The polymeric micelles showed sustained and pH-induced accelerated release of doxorubicin.•The polymeric micelles showed mitochondria atargeting and DOX release in the cellular interior.•The polymeric micelles showed remarkable inhibition of tumor growth and Ki67 positive cells compared to the control group.
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Mitochondria-targeted,pH-triggered charge-convertible,Polymeric micelles,Drug delivery,Anticancer therapy
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