COVID-19 severity, cardiological outcome and immunogenicity of mRNA vaccine in adult patients with 22q11.2DS.

Federica Pulvirenti,Eva Piano Mortari,Carolina Putotto,Sara Terreri,Ane Fernandez Salinas,Bianca Laura Cinicola,Eleonora Cimini, Giulia Di Napoli,Eleonora Sculco,Cinzia Milito,Paolo Versacci,Chiara Agrati,Bruno Marino,Rita Carsetti,Isabella Quinti

The journal of allergy and clinical immunology. In practice（2022）

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摘要

SARS-CoV-2 infection had a mild course in most patients with 22q11.2DS, even in patients with major cardiovascular diseases. Immunization induced Spike-specific IgG responses and generated specific memory B and T cells. The weaker memory responses in patients with lymphopenia suggested the need for additional doses.

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关键词

22q11.2 deletion syndrome,CD4 T cells,COVID-19,Lymphopenia,SARS-CoV-2 infection,Specific T cells,Specific memory B cells,Spike antibody response,cardiovascular disease,mRNA BNT162b2 vaccine

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