Characterization of Patients in the International Severe Asthma Registry with High Steroid Exposure Who Did or Did Not Initiate Biologic Therapy.

Wenjia Chen,Mohsen Sadatsafavi,Trung N Tran,Ruth B Murray,Chong Boon Nigel Wong,Nasloon Ali,Cono Ariti,Esther Garcia Gil,Anthony Newell,Marianna Alacqua,Mona Al-Ahmad,Alan Altraja,Riyad Al-Lehebi,Mohit Bhutani,Leif Bjermer,Anne Sofie Bjerrum,Arnaud Bourdin,Lakmini Bulathsinhala,Anna von Bülow,John Busby,Giorgio Walter Canonica,Victoria Carter,George C Christoff,Borja G Cosio,Richard W Costello,J Mark FitzGerald,João A Fonseca,Kwang Ha Yoo,Liam G Heaney,Enrico Heffler,Mark Hew,Ole Hilberg,Flavia Hoyte,Takashi Iwanaga,David J Jackson,Rupert C Jones,Mariko Siyue Koh,Piotr Kuna,Désirée Larenas-Linnemann,Sverre Lehmann,Lauri A Lehtimäki,Juntao Lyu,Bassam Mahboub,Jorge Maspero,Andrew N Menzies-Gow,Concetta Sirena,Nikolaos Papadopoulos,Andriana I Papaioannou,Luis Pérez de Llano,Diahn-Warng Perng,Matthew Peters,Paul E Pfeffer,Celeste M Porsbjerg,Todor A Popov,Chin Kook Rhee,Sundeep Salvi,Camille Taillé,Christian Taube,Carlos A Torres-Duque,Charlotte S Ulrik,Seung Won Ra,Eileen Wang,Michael E Wechsler,David B Price

Journal of asthma and allergy（2022）

Cited 2|Views49

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Abstract

Around one third of severe HOCS asthma patients did not receive biologics despite a similar high burden of asthma exacerbations as those who initiated a biologic therapy. Other disease characteristics such as eosinophilic phenotype, serious infectious events, nasal polyps, airflow limitation and lack of asthma control appear to dictate biologic use.

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Key words

biologics,patient characteristics,real-world,severe asthma,treatment pattern

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