Synthesis and in vitro evaluation of antimycobacterial activity of two palladium(II) complexes based on 5-alkyl-1,3,4-oxadiazol-2(3H)-thione derivatives

Wesley Almeida Souza, Fernanda Manaia Demarqui,Angelina Maria de Almeida,Raphael Tristao Cruvinel Silva, Douglas Alexsander Alves,Thaise Goncalves Araujo,Jackson Antonio Lamounier Camargos Resende,Fernando Rogerio Pavan,Helio Ferreira Dos Santos,Mauro Vieira de Almeida,Wendell Guerra

Journal of Molecular Structure（2022）

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摘要

•Two palladium(II) complexes containing mixed ligands were prepared.•One of them showed good activity against Mycobacterium tuberculosis.•Antitubercular activity decreased with increasing alkyl chain length.•Both were not cytotoxic against prostate and breast cell lines.

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关键词

Tuberculosis,Palladium complexes,Mycobacterium tuberculosis,Cytotoxicity,1,3,4-oxadiazole-2-(3H)-thione, DFT

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