Modified pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as EGFRWT and EGFRT790M inhibitors: Design, synthesis, and anti-cancer evaluation

Eman S. Nossier,Rania A. Alasfoury,Mohamed Hagras,May El-Manawaty,Sara M. Sayed,Ibrahim M. Ibrahim,Hazem Elkady,Ibrahim H. Eissa,Heba S. A. Elzahabi

Journal of Molecular Structure（2022）

Cited 9|Views8

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Abstract

•Thirteen compounds of novel pyrido[2,3-d]pyrimidin-4(3H)-one derivatives were designed and synthesized.•Cytotoxic activities were evaluated against A-549, PC-3, HCT-116, and MCF-7 cell lines.•In vitro anti EGFRWT and EGFRT790M activities were evaluated.•Molecular docking studies were carried out against EGFRWT and EGFRT790M.

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Key words

Anticancer,EGFR inhibitors,Mechanistic studies,Docking,Pyrido[2,3-d]pyrimidin-4(3H)-one

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