Herrmananes A and B, two new sulfated hydrocarbons from the sea cumber Stichopus herrmanni

Using various chromatographic separations, two new sulfated hydrocarbons namely herrmananes A and B (1 and 2) were isolated from the aqueous fraction of the methanol residue of the sea cucumber Stichopus herrmanni. Their chemical structures were elucidated by extensive analysis of the 1D, 2D NMR and HR-QTOF mass spectra. In addition, compound 1 showed significant cytotoxicity on SK-Mel-2 cell line with IC50 value of 23.12 +/- 1.87 mu M, whereas 2 exhibited moderate effect on this cell line with IC50 value of 55.28 +/- 4.17 mu M.