Exploring the interaction of dietary fiber hydroxypropyl methylcellulose and biosurfactant sodium deoxycholate

The interaction of dietary fiber and biosurfactant bile salt, and the fundamental concept of their aggregation process, may have implications for food formulations and pharmaceuticals. In this work, we have tried to explore the interaction between a simple dietary fiber hydroxypropyl methylcellulose (HPMC) and bile salt sodium deoxycholate (NaDC) by bringing almost all fundamental aspects of their aggregation process and physicochemical properties. The polarity parameter of fluorescent probe molecule pyrene and conventional conductivity method has been used to collect information on aggregation number ( N agg ), critical aggregation concentration (CAC), and critical micellar concentration (CMC) of the HPMC/NaDC mixed system. The nature of micellization was found to be a feasible and spontaneous process from the calculated thermodynamic parameters, i.e., standard entropy ( ΔS_mic^0 ), standard enthalpy ( ΔH_mic^0 ), and Gibbs free energy ( ΔG_mic^0 ). The dynamic light scattering and zeta potential measurements were carried out to get more information on the size distribution of HPMC/NaDC mixed system at different regions of their interaction and to have a better insight into their interaction. Graphical abstract