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Rearranged Dichapetalin-Type Triterpenoids with Cytotoxic Activity from Dichapetalum gelonioides

Xin-Hua Gao, Xi-Yuan Wang, Jun-Su Zhou, Yan Zhang, Hong-Chun Liu, Bin Zhou, Jian-Min Yue

CHINESE JOURNAL OF CHEMISTRY（2022）

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Abstract
Comprehensive Summary Dichagelinoids A-C (1-3), three unusual dichapetalin-type triterpenoids, together with two biogenetically related derivatives dichagelinoids D and E (4 and 5) were isolated and characterized by solid data from Dichapetalum gelonioides. Compounds 1-3 possess a common rearranged C ring and different C6-C2 modified motifs at the A rings. Biological evaluation revealed that compounds 1-3 showed distinct cytotoxic activity against the tested human cancer cell lines.
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Key words
Dichapetalum gelonioides,Natural products,Dichapetalin-type triterpenoids,Structural elucidation,Cytotoxic activity
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