Silver nanoparticle production mediated by Goniothalamus wightii extract: characterization and their potential biological applications

The focal aim of the study was to prepare silver nanoparticles (AgNPs) derived from the leaf extract of Goniothalamus wightii (Gw) and determine the potential bio-applications. The presence of biosynthesized Gw-AgNPs and composition was confirmed by UV visible spectroscopy, and XRD analysis. The FT-IR spectrum was used to confirm the existence of different functional groups that act as capping and reducing agents. Zeta revealed the surface negative charge, and HR-TEM confirmed the spherical form of the Gw-AgNPs. The anti-bacterial activity was tested on four pathogen Pseudomonas aeruginosa, Staphylococcus epidermidis, S. aureus and Escherichia coli, exhibits a strong toxic activity against microorganism and the results recorded that Gw-AgNPs could be a promising antioxidant agent. The Gw-AgNPs against MCF-7 cells is about 50% and holds at 40 mu g/mL in 24 h and 60 mu g/mL in 48 h. The larvicidal activity of Gw-AgNPs at various concentrations against fourth instar larvae treated, had the highest mortality rate in Aedes aegypti and culex quinquefasciatus (83.33%) 25 mg/L for 48 h and the environmental effects of photocatalytic degradation activities against methylene blue and highest degradation was observed at 98% within 150 min. Overall the results of the study established that the importance of Gw-AgNPs and could be used as potent disruptive bio-material for biomedical and pharma-industrial applications.