Plagranline A, a Novel beta-carboline and the First Alkaloid Isolated from Platycodon grandiflorus
RECORDS OF NATURAL PRODUCTS(2023)
Abstract
A novel beta-carboline, namely Plagranline A (1), and a known alkaloid (2) were isolated from the roots of Platycodon grandiflorus. Their structure was elucidated using a combination of spectroscopic analyses and computational chemistry, including electronic circular dichroism (ECD) and optical rotatory dispersion (ORD). Alkaloids 1 and 2 exhibited moderate inhibitory effects against NO production. Interestingly, 1 and 2 are the first alkaloid constituents reported from the plant P. grandifloras.
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Key words
Platycodon grandiflorus, beta-carboline, computational chemistry, alkaloid, anti-inflammatory activity
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