Evaluation of a gold nanocomposite hyaluronic acid-based adhesion barrier with antibacterial properties in an animal model

Objectives: In this study, the effects of a gold nanocomposite hyaluronic acid-based adhesion barrier were evaluated in an animal model. Materials and methods: In our study, a total of 42 rats in seven groups, with six rats in each group, were evaluated. The groups were established according to the application of an adhesion barrier. In the first, second, and third groups, an adhesion barrier was applied by standard median laparotomy in the first, second, and fourth weeks, respectively. The fourth, fifth, and sixth groups underwent the same procedure in the first, second, and fourth weeks; however, no adhesion barrier was applied to these groups. The seventh group was the control group, and no treatment was performed in this group. Results: There was no significant difference in the formation of inflammatory cells and fibrous tissue between the groups that underwent laparotomy in the first and second weeks with and without the adhesion barrier (p>0.05). However, both low inflammatory cells (p<0.05) and low fibrous tissue (p<0.05) were evaluated in favor of the adhesion barrier group operated at the fourth week. Conclusion: A gold nanocomposite hyaluronic acid-based adhesion barrier prevents adhesion, particularly in the long term. However, the results need to be supported by clinical studies.