Enhanced delivery of antibodies across the blood-brain barrier via TEMs with inherent receptor-mediated phagocytosis

Suzanne Edavettal, Pilar Cejudo-Martin, Bidisha Dasgupta,Danlin Yang, Matthew D Buschman, Derrick Domingo,Kristof Van Kolen,Pharavee Jaiprasat, Renata Gordon, Keith Schutsky,Brian Geist,Natalie Taylor, Camille Helene Soubrane, Elisabeth Van Der Helm, Ann LaCombe, Zemeda Ainekulu,Eilyn Lacy,Jason Aligo, Jason Ho,Yingbo He, Peter F Lebowitz,James T Patterson,Justin M Scheer,Sanjaya Singh

Med（2022）

引用 16|浏览3

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摘要

•Optimization of brain delivery module kinetic properties for enhanced uptake•Discovery of a non-classical phagocytosis mechanism to safely clear proteins and cells•Potential applications in neurological disorders and brain cancer treatments

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关键词

blood-brain barrier,brain metastasis,antibody exposure in brain,Alzheimer's disease,her2,tau,TfR,CD98,receptor-mediated transcytosis,phagocytosis

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