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Proprotein Convertase Subtilisin/Kexin 9 Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms.

Shunsuke Katsuki,Prabhash Kumar Jha,Adrien Lupieri,Toshiaki Nakano,Livia S A Passos,Maximillian A Rogers,Dakota Becker-Greene,Thanh-Dat Le,Julius L Decano,Lang Ho Lee,Gabriel C Guimaraes,Ilyes Abdelhamid,Arda Halu,Alessandro Muscoloni,Carlo Vittorio Cannistraci,Hideyuki Higashi,Hengmin Zhang,Amélie Vromman,Peter Libby,C Keith Ozaki,Amitabh Sharma,Sasha A Singh,Elena Aikawa,Masanori Aikawa

Circulation research（2022）

Cited 8|Views36
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Abstract
Circulating PCSK9 induces macrophage activation and vein graft lesion development via LDLR-independent mechanisms. PCSK9 may be a potential target for pharmacologic treatment for this unmet medical need.
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Key words
LDL receptor,inflammation,macrophage activation,systems biology,vein graft failure
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