Proprotein Convertase Subtilisin/Kexin 9 Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms.
Circulation research(2022)
Abstract
Circulating PCSK9 induces macrophage activation and vein graft lesion development via LDLR-independent mechanisms. PCSK9 may be a potential target for pharmacologic treatment for this unmet medical need.
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Key words
LDL receptor,inflammation,macrophage activation,systems biology,vein graft failure
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