Microvascular perfusion, perfused boundary region and glycocalyx shedding in patients with autosomal dominant polycystic kidney disease: results from the GlycoScore III study.

Alexander Fuchs, Jennifer Dederichs,Sita Arjune,Polina Todorova, Fabian Wöstmann,Philipp Antczak,Anja Illerhaus,Birgit Gathof,Franziska Grundmann,Roman-Ulrich Müller,Thorsten Annecke

Clinical kidney journal（2023）

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摘要

Dimensions and integrity of the ESL are impaired in ADPKD patients. Increased capillary density may be a compensatory mechanism for vascular dysfunction to ensure sufficient tissue perfusion and oxygenation.

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关键词

ADPKD,endothelium,glycocalyx,intravital microscopy,microcirculation

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