Associations of PFAS-related plasma metabolites with cholesterol and triglyceride concentrations

T Schillemans, I A Bergdahl,K Hanhineva, L Shi,C Donat-Vargas, J Koponen, H Kiviranta,R Landberg, A Åkesson,C Brunius

Environmental Research(2023)

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摘要
The wide-spread environmental pollutants per- and polyfluoroalkyl substances (PFAS) have repeatedly been associated with elevated serum cholesterol in humans. However, underlying mechanisms are still unclear. Furthermore, we have previously observed inverse associations with plasma triglycerides. To better understand PFAS-induced effects on lipid pathways we investigated associations of PFAS-related metabolite features with plasma cholesterol and triglyceride concentrations.
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关键词
Per- and polyfluoroalkyl substances,Metabolomics,Cholesterol,Triglycerides,HBM4EU
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