Prostaglandin EP3 receptor activation is antinociceptive in sensory neurons via PI3Kγ, AMPK and GRK2.
British journal of pharmacology（2022）
Abstract
Activation of neuronal PI3Kγ, AMPK, and GRK2 by EP3 receptor activation limits cAMP-dependent pain generation by prostaglandin E . These new insights hold the potential for a novel approach in pain therapy.
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Key words
EP3 receptor,GRK2,PGE2,PI3Kγ,antinociception,pain,sensory neuron
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