Effect of SARS-CoV-2 vaccine booster on HIV reservoirs and immune markers

M Ali Rai,Victoria Shi,Brooke D Kennedy,Jesse S Justement,Kathleen Gittens,Genevieve McCormack,Jana Blazkova,Susan Moir,Tae-Wook Chun

Open Forum Infectious Diseases（2022）

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摘要

Abstract We investigated effects of the SARV-CoV-2 booster vaccination on HIV reservoir size, immune markers, and host immune responses in PWH receiving ART. Our data suggest that the SARS-CoV-2 booster vaccine is not likely to replenish the persistent HIV reservoir nor provide an immunologic environment to facilitate active HIV expression/replication.

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