High-Dose Methotrexate in Patients With Lymphoma: Predictors of a Complicated Course.

JCO oncology practice（2022）

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摘要

Elevated MTX levels are associated with a significant increased rate of AKI, ICU admission, prolonged LOS, and 30-day mortality. Elevated 48-hour MTX levels, particularly > 1.28 μmol/L, should alert clinicians for complications and to initiate measures to reduce MTX levels.

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methotrexate,lymphoma,high-dose

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