Fatigue life evaluation for notched single-crystal Ni-based superalloys considering inhomogeneous rafting microstructure

•A framework for fatigue life prediction of notched single crystal Ni-based superalloys with inhomogeneous rafting is established.•A novel strain energy density is proposed considering the effect of microstructural rafting on plastic and elastic parts.•Deformation of degraded materials near the central hole is depicted by a microstructure-sensitive constitutive model.•The uncertainty of predicted life induced by microstructure statistics is evaluated based on the distribution of the real microstructural features.