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Synergetic effect of high dose rate radiations ( 10 × FFF /2400 MU /min/10 MV x‐rays) and paclitaxel selectively eliminates melanoma cells

Niraj Lodhi,Poonam Nagpal,Sreeja Sarojini,Michaela Keck, Yuk Ming Chiu, Zeenath Parvez,Laura Adrianzen,K. Stephen Suh

Cancer Reports（2022）

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Abstract
Our study indicates that radiations with paclitaxel have a potential synthetic lethal effect on melanoma cells and can be developed as a melanoma therapy without toxicities or harmful effects on normal primary skin cells.
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PARP1,apoptosis,combination radio-chemotherapy,flash radiation therapy,melanoma,synthetic lethality
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