Digital pathology with artificial intelligence analyses provides greater insights into treatment-induced fibrosis regression in NASH

•AI revealed antifibrotic effects of TXR, unlike conventional microscopy.•Spatial correlation between fibrosis and steatosis reduction suggests that anti-metabolic therapies initially drive fibrosis regression in the perisinusoidal regions.•Regressive changes in septa morphology and collagen fiber parameters observed in patients with F3 fibrosis, who were considered ‘unchanged’ with conventional scoring.•Digital pathology provides quantitative details of fibrosis dynamics with novel insights into treatment-induced fibrosis regression in NASH.