Transition‐Metal Free C(sp3)‐H Sulfonylation for the Synthesis of 2‐Sulfolmethyl Quinolines from 2‐Methylquinolines and Sulfonyl Hydrazides
Asian Journal of Organic Chemistry(2022)
Abstract
An efficient and transition metal-free C(sp(3))-H sulfonylation method is described for the synthesis of 2-sulfolmethyl quinolines from 2-methylquinolines and the inexpensive sulfonyl hydrazides. Generally, this protocol uses KI as an additive in the presence of the oxidant tert-butyl peroxybenzoate (TBPB), an efficient and compatible benign method that delivers 2-sulfolmethyl quinolines products in moderate to good yields.
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Key words
C(sp(3))-H sulfonylation, sulfones, sulfonyl hydrazide, transition-metal-free
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